TP53 Network (Homo sapiens)

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Grown arrest and apoptosis Grown arrest and apoptosis Apoptosis Different isoforms of the protein Reduces transcriptional activity but does not induce degradation ABL1 SUMO-1 MYC TP53 CDKN2A TP73 IGFBP-3 TP63 ATM OTX2 TNFSF10 TP73 Delta Np73 TP73zeta TP73delta TP73alpha TP73gamma TP73beta TP73epsilon BID BCL2 DeltaNp63gamma TAp63beta DelatNp63alpha TAp63gamma TAp63alpha DeltaNp63beta BOK PMAIP1 BBC3 CDKN1A BAX GADD45A MDM2 Name: TP53 Network License: CC BY 2.0 Organism: Homo sapiens


Description

P53 is not a lonely genome guardian, it operates with the assistance of p73 and p63 within a complex network including distinct but complementary pathways. This protein family presents a high level of sequence homology in its DNA binding domain. The complexity of the family has been enriched by the alternatively spliced forms of the genes. At present pathway, the alternatively spliced forms of p63 and p73 and how they interact with p53 are shown . However, little is known about the transcriptional regulation of p53 family members. Further studies will tell us whether the three genes of the family also share others regulatory activities.

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Ontology Terms

<OntologyTags></OntologyTags>

Bibliography

  1. Bunt J, de Haas TG, Hasselt NE, Zwijnenburg DA, Koster J, Versteeg R, Kool M; ''Regulation of Cell Cycle Genes and Induction of Senescence by Overexpression of OTX2 in Medulloblastoma Cell Lines.''; Mol Cancer Res, 2010 PubMed
  2. Shaul Y; ''c-Abl: activation and nuclear targets.''; Cell Death Differ, 2000 PubMed
  3. Yang A, Kaghad M, Wang Y, Gillett E, Fleming MD, Dötsch V, Andrews NC, Caput D, McKeon F; ''p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities.''; Mol Cell, 1998 PubMed
  4. Ishimoto O, Kawahara C, Enjo K, Obinata M, Nukiwa T, Ikawa S; ''Possible oncogenic potential of DeltaNp73: a newly identified isoform of human p73.''; Cancer Res, 2002 PubMed
  5. Yuan ZM, Shioya H, Ishiko T, Sun X, Gu J, Huang YY, Lu H, Kharbanda S, Weichselbaum R, Kufe D; ''p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage.''; Nature, 1999 PubMed
  6. Dohn M, Zhang S, Chen X; ''p63alpha and DeltaNp63alpha can induce cell cycle arrest and apoptosis and differentially regulate p53 target genes.''; Oncogene, 2001 PubMed
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History

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RevisionActionTimeUserComment
95548view 07:32, 22 December 2017DeSlCOnnected more unconencted lines, changed several lines to graphical lines.
95475view 16:43, 17 December 2017AndraConnected lines
95435view 22:30, 14 December 2017MaintBotfixed xref
71700view 12:51, 17 October 2013MaintBotUpdated data sources
70104view 11:54, 12 July 2013MaintBotupdated to 2013 schema
70032view 18:57, 11 July 2013AlexanderPicoModified title
59109view 15:22, 21 February 2013MaintBotUpdated Ensembl data source
48062view 11:41, 1 May 2012KhanspersReplaced special characters
48060view 11:14, 1 May 2012KhanspersPeriodical save, work in progress
45074view 13:17, 6 October 2011KhanspersOntology Term : 'cancer' added !
45073view 13:16, 6 October 2011KhanspersOntology Term : 'p53 signaling pathway' added !
41057view 16:17, 1 March 2011MaintBotRemoved redundant pathway information and comments
39274view 15:33, 9 November 2010AlexanderPicoModified categories
39273view 15:32, 9 November 2010AlexanderPicoconnected line from SUMO-1 to TP53
39272view 15:30, 9 November 2010AlexanderPicospecified xref systems, e.g., Entrez, UniProt or Ensembl
39264view 04:17, 8 November 2010GlendaPeriodical save, work in progress
39263view 03:56, 8 November 2010GlendaPeriodical save, work in progress
39262view 03:36, 8 November 2010GlendaPeriodical save, work in progress
39261view 02:54, 8 November 2010GlendaPeriodical save, work in progress
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39205view 00:57, 28 October 2010GlendaPeriodical save, work in progress
39204view 00:47, 28 October 2010GlendaPeriodical save, work in progress
39203view 00:10, 28 October 2010GlendaModified description
39202view 22:03, 27 October 2010GlendaModified description
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External references

DataNodes

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NameTypeDatabase referenceComment
ABL1GeneProduct25 (Entrez Gene)
ATMGeneProductENSG00000149311 (Ensembl)
BAXGeneProduct581 (Entrez Gene)
BBC3GeneProduct27113 (Entrez Gene)
BCL2GeneProductENSG00000171791 (Ensembl)
BIDGeneProductENSG00000015475 (Ensembl)
BOKGeneProduct666 (Entrez Gene)
CDKN1AGeneProductENSG00000124762 (Ensembl)
CDKN2AGeneProduct1029 (Entrez Gene)
DelatNp63alphaProteinQ9H3D4 (Uniprot-TrEMBL)
DeltaNp63betaProteinQ9H3D4 (Uniprot-TrEMBL)
DeltaNp63gammaProteinQ9H3D4 (Uniprot-TrEMBL)
GADD45AGeneProduct1647 (Entrez Gene)
IGFBP-3GeneProductENSG00000235943 (Ensembl)
MDM2GeneProductENSG00000135679 (Ensembl)
MYCGeneProduct4609 (Entrez Gene)
OTX2GeneProductENSG00000165588 (Ensembl)
PMAIP1GeneProduct5366 (Entrez Gene)
SUMO-1Protein7341 (Entrez Gene)
TAp63alphaProteinQ9H3D4 (Uniprot-TrEMBL)
TAp63betaProteinQ9H3D4 (Uniprot-TrEMBL)
TAp63gammaProteinQ9H3D4 (Uniprot-TrEMBL)
TNFSF10GeneProduct8743 (Entrez Gene)
TP53GeneProduct7157 (Entrez Gene)
TP63GeneProduct8626 (Entrez Gene)
TP73 Delta Np73ProteinO15350 (Uniprot-TrEMBL)
TP73GeneProduct7161 (Entrez Gene)
TP73alphaProteinO15350 (Uniprot-TrEMBL)
TP73betaProteinO15350 (Uniprot-TrEMBL)
TP73deltaProteinO15350 (Uniprot-TrEMBL)
TP73epsilonProteinO15350 (Uniprot-TrEMBL)
TP73gammaProteinO15350 (Uniprot-TrEMBL)
TP73zetaProteinO15350 (Uniprot-TrEMBL)

Annotated Interactions

<cite>No annotated interactions</cite>