Folate-Alcohol and Cancer Pathway Hypotheses (Homo sapiens)

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Methyltransferases DNA Methylated DNA NUCLEUS NON-COMPETITIVE INHIBITION Nucleotide Synthesis ALDH1A1 THF MTR Cystathionine Methionine SAM ALDH1A1 C/EBPB Acetaldehyde Acetate CYP2E1 SAH Homocysteine Folate ADH5 CREB1 CYP2E1 ALDH1L1 MTHFR 5,10-Methylene-THF Ethanol 5-Methyl THF ALDH1L1 Cysteine CBS Name: Folate-Alcohol and Cancer Pathway Hypotheses License: CC BY 2.0 Organism: Homo sapiens


As described in Hwang, et al., "The interaction of folate and alcohol consumption has been shown to have an antagonistic effect on the risk of oral cancer. Studies have demonstrated that increased intake of folate decreases the risk of oral cancer, while greater alcohol consumption has an opposite effect." This pathway is a hypothetical model for a causal role for P450 2E1 (CYP2E1) and aldehyde dehydrogenase 1 (ALDH1) in oral cancers, implicating folate (via SAM) and alcohol.

Quality Tags

Ontology Terms



  1. Hwang PH, Lian L, Zavras AI; ''Alcohol intake and folate antagonism via CYP2E1 and ALDH1: effects on oral carcinogenesis.''; Med Hypotheses, 2012 PubMed


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96101view 16:23, 15 February 2018AlexanderPicoOntology Term : 'oral cavity cancer' added !
96100view 16:22, 15 February 2018AlexanderPicoModified description
96099view 16:15, 15 February 2018AlexanderPicoModified title
96098view 16:14, 15 February 2018AlexanderPicoclarified layout and interations; added MTR
92113view 11:55, 28 April 2017EgonwRemoved a lone metabolite node.
87508view 18:49, 24 July 2016AlexanderPicoOntology Term : 'cancer pathway' added !
87507view 18:49, 24 July 2016AlexanderPicoOntology Term : 'disease pathway' added !
82223view 20:26, 15 September 2015AlexanderPicofixed catalysis for biopax conversion
78797view 06:00, 30 January 2015EgonwAdded missing metabolite identifiers.
78796view 05:51, 30 January 2015EgonwConnected dots.
74018view 06:36, 22 March 2014EgonwAdded a few metabolite identifiers.
62366view 16:57, 27 April 2013AlexanderPicoFixed gene and metabolite annotations
45285view 12:11, 7 October 2011AlexanderPicoadded nucleus
45284view 12:10, 7 October 2011AlexanderPicofixed reactions
45282view 12:08, 7 October 2011AlexanderPicofixed gene labels
41113view 16:36, 1 March 2011MaintBotRemoved redundant pathway information and comments
38167view 15:39, 20 August 2010KhanspersAdded xrefs
38166view 15:24, 20 August 2010KhanspersAdded xrefs
38165view 15:21, 20 August 2010KhanspersPeriodical save, work in progress
38164view 15:11, 20 August 2010KhanspersPeriodical save, work in progress
38163view 15:00, 20 August 2010KhanspersPeriodical save, work in progress
38147view 12:01, 17 August 2010KhanspersModified categories
37896view 12:18, 13 July 2010WhomNew pathway

External references


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NameTypeDatabase referenceComment
5,10-Methylene-THFMetaboliteHMDB01533 (HMDB)
5-Methyl THFMetaboliteCHEBI:15641 (ChEBI)
ADH5GeneProductENSG00000197894 (Ensembl)
ALDH1A1GeneProduct216 (Entrez Gene)
ALDH1L1GeneProduct10840 (Entrez Gene)
AcetaldehydeMetaboliteHMDB00990 (HMDB)
AcetateMetaboliteCHEBI:30089 (ChEBI)
C/EBPBGeneProduct1051 (Entrez Gene)
CBSGeneProduct875 (Entrez Gene)
CREB1GeneProduct1385 (Entrez Gene)
CYP2E1GeneProduct1571 (Entrez Gene)
CystathionineMetaboliteHMDB00099 (HMDB)
CysteineMetaboliteHMDB00574 (HMDB)
EthanolMetaboliteHMDB00108 (HMDB)
FolateMetaboliteCHEBI:62501 (ChEBI)
HomocysteineMetaboliteHMDB00742 (HMDB)
MTHFRGeneProduct4524 (Entrez Gene)
MTRGeneProductENSG00000116984 (Ensembl)
MethionineMetaboliteHMDB00696 (HMDB)
Nucleotide SynthesisPathwayWP404 (WikiPathways)
SAHMetaboliteCHEBI:16680 (ChEBI)
SAMMetabolite8041295 (Chemspider)
THFMetaboliteCHEBI:20506 (ChEBI)

Annotated Interactions

<cite>No annotated interactions</cite>