Target Of Rapamycin (TOR) Signaling (Homo sapiens)

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Amino acids mTORC1 mTORC2 AMPK Hypoxia Survival high AMP:ATP RAC1 CDC42 RHEB HMGCR PRR5 RPS6KB1 Ribosome biogenesis Insulin signaling AKT1 Myelination Insulin signaling mRNA translation IDI1 AKT1S1 PRR5L Actin Organization Autophagy PRKCA Cytoskeletal dynamics SREPB2 EIF4EBP1 RPTOR MLST8 MTOR FKBP1A Rapamycin DDIT4 DDIT4L RRAGC RRAGD RRAGB RRAGA ULK1 ULK3 ULK2 MLST8 MTOR MAPKAP1 RICTOR PRKAB1 PRKAG3 PRKAB2 PRKAG1 PRKAA2 PRKAA1 PRKAG2 TSC2 TSC1 Amino acids Name: Target Of Rapamycin (TOR) Signaling License: CC BY 2.0 Last Modified: 2/22/2013 Organism: Homo sapiens


Description

TOR signaling is responsible for a cellular reaction towards nutrient and energy availability and hypoxia/stress. The mammalian Target Of Rapamycin (mTOR), a serine/threonine kinase, is the central regulator that consists in two different complexes: a rapamycin-sensitive complex (mTORC1) consisting of mTOR, Raptor and GbetaL that regulates mRNA translation, ribosome biogenesis and autophagy and a second rapamycin-insensitive complex (mTORC2) consisting of mTOR, Rictor GbetaL, Sin1 and Protor 1/2 that regulates survival and a cytoskeletal response. TOR signaling is highly integrated in other signaling pathways that respond to external conditions, such as the insulin-signaling cascade and AMPK signaling.

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Ontology Terms

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Bibliography

  1. Inoki K, Guan KL; ''Complexity of the TOR signaling network.''; Trends Cell Biol, 2006 PubMed
  2. Yang Q, Guan KL; ''Expanding mTOR signaling.''; Cell Res, 2007 PubMed
  3. Corradetti MN, Guan KL; ''Upstream of the mammalian target of rapamycin: do all roads pass through mTOR?''; Oncogene, 2006 PubMed
  4. Sancak Y, Sabatini DM; ''Rag proteins regulate amino-acid-induced mTORC1 signalling.''; Biochem Soc Trans, 2009 PubMed
  5. Wullschleger S, Loewith R, Hall MN; ''TOR signaling in growth and metabolism.''; Cell, 2006 PubMed
  6. Norrmén C, Figlia G, Lebrun-Julien F, Pereira JA, Trötzmüller M, Köfeler HC, Rantanen V, Wessig C, van Deijk AL, Smit AB, Verheijen MH, Rüegg MA, Hall MN, Suter U; ''mTORC1 controls PNS myelination along the mTORC1-RXRγ-SREBP-lipid biosynthesis axis in Schwann cells.''; Cell Rep, 2014 PubMed
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History

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RevisionActionTimeUserComment
94755view 08:33, 5 October 2017Mkutmonfix unconnected line
90258view 13:01, 27 October 2016AlexanderPicoupdated compartment and graphical object types
86079view 03:06, 29 June 2016MirellaKalafatiModified title
82750view 20:25, 26 October 2015Jlw9added components of myelination pathway
82749view 20:15, 26 October 2015Jlw9Periodical save, work in progress
82748view 19:55, 26 October 2015Jlw9Periodical save, work in progress
82747view 19:45, 26 October 2015Jlw9Periodical save, work in progress
82219view 19:39, 15 September 2015AlexanderPicoclarified interactions for biopax conversion
70031view 18:57, 11 July 2013AlexanderPicoModified title
69007view 10:46, 8 July 2013MaintBotUpdated to 2013 gpml schema
61698view 16:24, 16 April 2013MaintBotremoved data source without identifer
60230view 13:12, 14 March 2013EgonwReplaced PubChem-substance with PubChem-compound.
60227view 13:10, 14 March 2013EgonwAnnotated 'amino acid' with an ChEBI entry.
59195view 12:07, 22 February 2013MaintBotUpdated Ensembl and UniProt data source
48241view 23:07, 16 May 2012MaintBotUpdating PubChem xrefs
45081view 13:42, 6 October 2011KhanspersOntology Term : 'insulin signaling pathway' added !
45080view 13:41, 6 October 2011KhanspersOntology Term : 'AMPK signaling pathway' added !
45078view 13:40, 6 October 2011KhanspersOntology Term : 'mTOR signaling pathway' added !
41181view 16:42, 1 March 2011MaintBotRemoved redundant pathway information and comments
38698view 12:08, 23 September 2010AlexanderPicopathway nodes
38691view 11:26, 23 September 2010AlexanderPicoadded pathway nodes; altered labels for conditions and phenotypes
36157view 09:59, 3 March 2010Pieter GiesbertzSpecify description
36156view 08:53, 3 March 2010Pieter GiesbertzModified categories
36155view 08:48, 3 March 2010Pieter GiesbertzSpecify description
36140view 05:31, 3 March 2010Pieter GiesbertzSpecify description
36139view 05:15, 3 March 2010Pieter GiesbertzPeriodical save, work in progress
36138view 04:44, 3 March 2010Pieter GiesbertzModified description
36137view 04:41, 3 March 2010Pieter GiesbertzPeriodical save, work in progress
36095view 03:09, 3 March 2010Pieter GiesbertzAdded literature
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36040view 01:35, 3 March 2010Pieter GiesbertzPeriodical save, work in progress
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36011view 08:40, 1 March 2010Pieter GiesbertzPeriodical save, work in progress

External references

DataNodes

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NameTypeDatabase referenceComment
AKT1GeneProductENSG00000142208 (Ensembl)
AKT1S1GeneProductENSG00000204673 (Ensembl)
Actin OrganizationPathway
AutophagyPathway
CDC42GeneProductENSG00000070831 (Ensembl)
Cytoskeletal dynamicsPathway
DDIT4GeneProductENSG00000168209 (Ensembl)
DDIT4LGeneProductENSG00000145358 (Ensembl)
EIF4EBP1GeneProductENSG00000187840 (Ensembl)
FKBP1AGeneProductENSG00000088832 (Ensembl)
HMGCRGeneProduct3156 (Entrez Gene)
IDI1GeneProductENSG00000067064 (Ensembl)
Insulin signalingPathwayWP481 (WikiPathways)
MAPKAP1GeneProductENSG00000119487 (Ensembl)
MLST8GeneProductENSG00000167965 (Ensembl)
MTORGeneProductENSG00000198793 (Ensembl)
MyelinationPathway
PRKAA1GeneProductENSG00000132356 (Ensembl)
PRKAA2GeneProductENSG00000162409 (Ensembl)
PRKAB1GeneProductENSG00000111725 (Ensembl)
PRKAB2GeneProductENSG00000131791 (Ensembl)
PRKAG1GeneProductENSG00000181929 (Ensembl)
PRKAG2GeneProductENSG00000106617 (Ensembl)
PRKAG3GeneProductENSG00000115592 (Ensembl)
PRKCAGeneProductENSG00000154229 (Ensembl)
PRR5GeneProductENSG00000186654 (Ensembl)
PRR5LGeneProductENSG00000135362 (Ensembl)
RAC1GeneProductENSG00000136238 (Ensembl)
RHEBGeneProductENSG00000106615 (Ensembl)
RICTORGeneProductENSG00000164327 (Ensembl)
RPS6KB1GeneProductENSG00000108443 (Ensembl)
RPTORGeneProductENSG00000141564 (Ensembl)
RRAGAGeneProductENSG00000155876 (Ensembl)
RRAGBGeneProductENSG00000083750 (Ensembl)
RRAGCGeneProductENSG00000116954 (Ensembl)
RRAGDGeneProductENSG00000025039 (Ensembl)
RapamycinMetabolite5497196 (PubChem-compound)
Ribosome biogenesisPathway
SREPB2GeneProduct
TSC1GeneProductENSG00000165699 (Ensembl)
TSC2GeneProductENSG00000103197 (Ensembl)
ULK1GeneProductENSG00000177169 (Ensembl)
ULK2GeneProductENSG00000083290 (Ensembl)
ULK3GeneProductENSG00000140474 (Ensembl)
mRNA translationPathwayWP107 (WikiPathways)

Annotated Interactions

<cite>No annotated interactions</cite>